This song off Lateralus is awesome...
standard tuning i believe

d------7h9-------7h9-7-
a-5h7-------5h7--------
d-0----0----0----0-----

thats it....
if ya wanna sound closer to it use certain effects
chorus with slow rate and some reverb and have a wah with the pedal towards the back to give more accent to the bass and act as a filter....chorus after wah in this case..then of course a dab of reverb